BDBM38236 CHEMBL522269::US10201527, Compound 48::US10736881, Compound 48::US8551988, 38

SMILES Cn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12

InChI Key InChIKey=MNTZTXLUYBQSMI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 38236   

TargetHistone deacetylase 8(Human)
Mei Pharma

US Patent
LigandPNGBDBM38236(CHEMBL522269 | US8551988, 38 | US10201527, Compoun...)
Affinity DataIC50: 148nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Mei Pharma

US Patent
LigandPNGBDBM38236(CHEMBL522269 | US8551988, 38 | US10201527, Compoun...)
Affinity DataIC50: 218nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Mei Pharma

US Patent
LigandPNGBDBM38236(CHEMBL522269 | US8551988, 38 | US10201527, Compoun...)
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant HDAC1 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Mei Pharma

US Patent
LigandPNGBDBM38236(CHEMBL522269 | US8551988, 38 | US10201527, Compoun...)
Affinity DataIC50: 291nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Mei Pharma

US Patent
LigandPNGBDBM38236(CHEMBL522269 | US8551988, 38 | US10201527, Compoun...)
Affinity DataIC50: 291nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Mei Pharma

US Patent
LigandPNGBDBM38236(CHEMBL522269 | US8551988, 38 | US10201527, Compoun...)
Affinity DataIC50: 356nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Mei Pharma

US Patent
LigandPNGBDBM38236(CHEMBL522269 | US8551988, 38 | US10201527, Compoun...)
Affinity DataIC50: 356nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
US Patent