BDBM383209 US10278929, Compound 5::US11337935, Compound 5

SMILES OC(=O)c1ccccc1Nc1cc(Cl)c(OCCOCCOCCNC(=S)Nc2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc23)c(Cl)c1

InChI Key InChIKey=MMJKDGSPMZTYNV-UHFFFAOYSA-N

Data  1 Kd  1 ITC

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 383209   

TargetTransthyretin(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM383209(US10278929, Compound 5 | US11337935, Compound 5)
Affinity DataKd:  820nMAssay Description:Dissociation Constants (Kd) associated with the binding of ligands to TTR are expressed in nM. Thermodynamic Binding Parameters associated with ligan...More data for this Ligand-Target Pair
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Date in BDB:
2/21/2020
Entry Details
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Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 383209   

CellTransthyretin(Human)
Leland Stanford Junior University

US Patent
SyringePNGBDBM383209(US10278929, Compound 5 | US11337935, Compound 5)
ITC DataΔG°: -8.31kcal/mole −TΔS°: -1.44kcal/mole ΔH°: -6.85kcal/mole logk: 1.25E+6
pH: 7.5 T: 25.00°C 
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