BDBM383245 4-(3-((6-methoxypyridin-3- yl)methyl)-4,5-dihydro3H- 1,2,2a1,5- tetraazaacenaphthylen-7-yl)- N-(1-methyl-1H-pyrazol-5- yl)pyrimidin-2-amine::US10278975, Compound I-24 S::US11376260, Example I-24S

SMILES COc1ccc(C[C@H]2CNc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cn1

InChI Key InChIKey=HXVZEPFNWAGNBV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 383245   

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM383245(4-(3-((6-methoxypyridin-3- yl)methyl)-4,5-dihydro3...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 6(Human)
Genentech

US Patent
LigandPNGBDBM383245(4-(3-((6-methoxypyridin-3- yl)methyl)-4,5-dihydro3...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
Go to US Patent