BDBM383455 N-(((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl- 5,6,7,8-tetrahydro-5,8- methanocinnolin-8-yl)methyl)-N- ethyl-5-methyloxazole-2- carboxamide::US10280144, Compound 171

SMILES CCN(C[C@@]12CC[C@@H](\C(=C\C(=N)c3c(F)cccc3F)C1=N)C2(C)C)C(=O)c1ncc(C)o1

InChI Key InChIKey=IEGCDIVPYUKTFQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 383455   

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandPNGBDBM383455(N-(((5R,8S)-3-(2,6- difluorophenyl)-9,9-dimethyl- ...)
Affinity DataIC50: 7.70nMAssay Description:Consumable Supplier and product code GFB Unifilter plates Perkin Elmer 6005177 3-[(3- Sigma C5070 Cholamidopropyl)dimethylammonio]- 1-propanesulfonat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
US Patent