BDBM384206 (2S,4R)-4-Amino-8-(3-(2-amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-2-ol::US10280171, Example 126::US10851110, Example 126::US11466017, Example 126

SMILES N[C@@H]1C[C@@H](O)CC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl

InChI Key InChIKey=DEODQFIAUXPGAK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 384206   

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384206(US10280171, Example 126 | (2S,4R)-4-Amino-8-(3-(2-...)
Affinity DataIC50: 75nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384206(US10280171, Example 126 | (2S,4R)-4-Amino-8-(3-(2-...)
Affinity DataIC50: 75nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384206(US10280171, Example 126 | (2S,4R)-4-Amino-8-(3-(2-...)
Affinity DataIC50: 75nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent