BDBM384381 (R)-N-(1-((1-(2-cyano-4,4-dimethylpent-2-enoyl)pyrrolidin-2-yl)methyl)-5-(hydroxymethyl)-1H-benzo[d]imidazol-2-yl)-5-(oxazol-5-yl)thiophene-2-carboxamide::US9932329, Cpd # 1

SMILES CC(C)(C)C=C(C#N)C(=O)N1CCC[C@@H]1Cn1c(NC(=O)c2ccc(s2)-c2cnco2)nc2cc(CO)ccc12

InChI Key InChIKey=MLHBMGYXWLXXSQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384381   

TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384381((R)-N-(1-((1-(2-cyano-4,4-dimethylpent-2-enoyl)pyr...)
Affinity DataIC50: 1.20nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384381((R)-N-(1-((1-(2-cyano-4,4-dimethylpent-2-enoyl)pyr...)
Affinity DataIC50: 1.40nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
US Patent