BDBM384537 N-1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyrrolidin-2-yl)methyl)-5-((((R)-1-methoxypropan-2-yl)amino)methyl)-1H-benzo[d]imidazol-2-yl)-5-(oxazol-5-yl)-thiophene-2-carboxamide formate::US9932329, Cpd # 7

SMILES COCC(C)NCc1ccc2n(C[C@H]3CCCN3C(=O)C(=CC(C)(C)C)C#N)c(NC(=O)c3ccc(s3)-c3cnco3)nc2c1

InChI Key InChIKey=COPLBPVGYVVHTD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384537   

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384537(N-1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyrr...)
Affinity DataIC50: 0.800nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
US Patent

TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384537(N-1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyrr...)
Affinity DataIC50: 2.10nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
US Patent