BDBM384623 4-{[trans-4-(4,4- difluoroazepan-1- yl)cyclohexyl]amino} quinazoline-6-carbonitrile::US9932350, 3-53

SMILES FC1(F)CCCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N

InChI Key InChIKey=NSMRASUIQDPHBL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 384623   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384623(US9932350, 3-53 | 4-{[trans-4-(4,4- difluoroazepan...)
Affinity DataIC50: 12nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
US Patent