BDBM384641 4-[(trans-4-{4-[(3- fluorocyclobutyl)carbonyl] piperazin-1- yl}cyclohexyl)amino] quinazoline-6-carbonitrile::US9932350, 6-13

SMILES FC1CC(C1)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N

InChI Key InChIKey=YPQWHEGTKXERCV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 384641   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384641(US9932350, 6-13 | 4-[(trans-4-{4-[(3- fluorocyclob...)
Affinity DataIC50: 10nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
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