BDBM384648 4-[(trans-4-{4- [cyclopropyl(hydroxy) acetyl]piperazin-1- yl}cyclohexyl)amino] quinazoline-6-carbonitrile::US9932350, 6-20

SMILES OC(C1CC1)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N

InChI Key InChIKey=WCLONIXUULMVLX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 384648   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384648(US9932350, 6-20 | 4-[(trans-4-{4- [cyclopropyl(hyd...)
Affinity DataIC50: 8nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
US Patent