BDBM384842 N-[(1R)-1-(4-cyclopropyl-3- fluorophenyl)-2,2-dimethylpropyl]-2- (dimethylamino)-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US10285989, Example 58

SMILES CN(C)c1nc(C(=O)N[C@@H](c2ccc(C3CC3)c(F)c2)C(C)(C)C)cc(=O)[nH]1

InChI Key InChIKey=UNOYCNBDKPELMH-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384842   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 384842BDBM384842(N-[(1R)-1-(4-cyclopropyl-3- fluorophenyl)-2,2-dime...)
Affinity DataKi:  0.0300nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 384842BDBM384842(N-[(1R)-1-(4-cyclopropyl-3- fluorophenyl)-2,2-dime...)
Affinity DataKi:  0.100nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent