BDBM385441 4-{(6R or S)-1-[(2- chloro-6- cyclopropylphenyl) carbonyl]-6-[(6-pyrimidin- 2-yl-2,6- diazaspiro[3.3]hept-2- yl)carbonyl]-4,5,6,7- tetrahydro-1H-indazol- 3-yl}cyclohex-3-ene-1- carboxylic acid::US10287272, Example 2XX::US10689369, Example 2XX

SMILES OC(=O)C1CCC(=CC1)c1nn(C(=O)c2c(Cl)cccc2C2CC2)c2CC(CCc12)C(=O)N1CC2(C1)CN(C2)c1ncccn1

InChI Key InChIKey=VPQZKMWQSDRRPY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 385441   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385441(4-{(6R or S)-1-[(2- chloro-6- cyclopropylphenyl) c...)
Affinity DataIC50: 2nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385441(4-{(6R or S)-1-[(2- chloro-6- cyclopropylphenyl) c...)
Affinity DataIC50: 2nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent