BDBM385952 US10287293, Example 1::US10287293, Example 2

SMILES C[C@@H](c1n[nH]c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=VGEZNJXGAIKFKY-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 385952   

LigandPNGBDBM385952(US10287293, Example 1 | US10287293, Example 2)
Affinity DataKi:  15nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM385952(US10287293, Example 1 | US10287293, Example 2)
Affinity DataKi:  15.2nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385952(US10287293, Example 1 | US10287293, Example 2)
Affinity DataKi:  17.8nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385952(US10287293, Example 1 | US10287293, Example 2)
Affinity DataKi:  293nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent