BDBM385968 (R)- or (S)-3- (1-(3- Fluoro- 4- (trifluoro- methyl) phenyl) ethyl)- 1-(2- fluoro- ethyl)- 5- methyl- 1,6- dihydro- 7H- pyrazolo [4,3-d]pyrimi-din-7-one::US10287293, Example 17::US10287293, Example 18

SMILES CC(c1nn(CCF)c2c1nc(C)[nH]c2=O)c1ccc(c(F)c1)C(F)(F)F

InChI Key InChIKey=OJRYADJLCLXEOS-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 385968   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385968(US10287293, Example 17 | (R)- or (S)-3- (1-(3- Fl...)
Affinity DataKi:  0.900nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385968(US10287293, Example 17 | (R)- or (S)-3- (1-(3- Fl...)
Affinity DataKi:  1nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385968(US10287293, Example 17 | (R)- or (S)-3- (1-(3- Fl...)
Affinity DataKi:  24.5nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent