BDBM385983 (R)- or (S)-5- (hydroxymethyl)-2- methyl-7-(1-(4- (trifluoromethoxy) phenyl)ethyl)imidazo [5,1-f][1,2,4]triazin- 4(3H)-one::US10287293, Example 32::US10287293, Example 33

SMILES CC(c1nc(CO)c2n1nc(C)[nH]c2=O)c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=NCYRSFJDSKMTLT-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 385983   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385983(US10287293, Example 32 | (R)- or (S)-5- (hydroxyme...)
Affinity DataKi:  1.20nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385983(US10287293, Example 32 | (R)- or (S)-5- (hydroxyme...)
Affinity DataKi:  62.5nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent