BDBM385985 (R)- or (S)-7-(1-(3- fluoro-4- (trifluoromethyl) phenyl)ethyl)-5- (hydroxymethyl)-2- methylimidazo[5,1- f][1,2,4]triazin- 4(3H)-one::US10287293, Example 34::US10287293, Example 35

SMILES CC(c1nc(CO)c2n1nc(C)[nH]c2=O)c1ccc(c(F)c1)C(F)(F)F

InChI Key InChIKey=BORCXXZYDYYMKI-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 385985   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385985(US10287293, Example 34 | US10287293, Example 35 | ...)
Affinity DataKi:  1nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385985(US10287293, Example 34 | US10287293, Example 35 | ...)
Affinity DataKi:  216nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent