BDBM386066 N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)oxy)methyl)- piperidin-3-yl)methanesulfonamide::US10287305, Example 4::US10508083, Example 4::US11292766, Example 4

SMILES CC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1

InChI Key InChIKey=JYJTZUGIUWJJIK-UHFFFAOYSA-N

Data  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 386066   

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386066(N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)o...)
Affinity DataEC50:  44nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386066(N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)o...)
Affinity DataEC50:  44nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386066(N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)o...)
Affinity DataEC50:  44nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386066(N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)o...)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386066(N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)o...)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386066(N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)o...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386066(N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)o...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386066(N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)o...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386066(N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)o...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed