BDBM386094 N-((2R,3S)-1-acetyl-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)- piperidin-3-yl)ethanesulfonamide::US10287305, Example 33::US10508083, Example 33::US11292766, Example 33

SMILES CCS(=O)(=O)N[C@H]1CCCN([C@H]1CO[C@H]1CC[C@H](CC1)C(C)C)C(C)=O

InChI Key InChIKey=BXCHBUYDFXKLTP-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 386094   

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386094(N-((2R,3S)-1-acetyl-2-(((cis-4- isopropylcyclohexy...)
Affinity DataEC50:  68nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386094(N-((2R,3S)-1-acetyl-2-(((cis-4- isopropylcyclohexy...)
Affinity DataEC50:  68nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386094(N-((2R,3S)-1-acetyl-2-(((cis-4- isopropylcyclohexy...)
Affinity DataEC50:  68nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386094(N-((2R,3S)-1-acetyl-2-(((cis-4- isopropylcyclohexy...)
Affinity DataEC50:  270nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386094(N-((2R,3S)-1-acetyl-2-(((cis-4- isopropylcyclohexy...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed