BDBM386112 N-(cis-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)-1-(3- phenylpropanoyl)piperidin-3- yl)methanesulfonamide::US10287305, Example 54::US10508083, Example 54::US11292766, Example 54

SMILES CC(C)[C@@H]1CC[C@@H](CC1)OC[C@H]1[C@H](CCCN1C(=O)CCc1ccccc1)NS(C)(=O)=O

InChI Key InChIKey=GYYBDAITWPSUTP-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 386112   

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386112(N-(cis-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)...)
Affinity DataEC50:  4.10E+3nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
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TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386112(N-(cis-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)...)
Affinity DataEC50:  4.10E+3nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386112(N-(cis-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)...)
Affinity DataEC50:  4.10E+3nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
Go to US Patent