BDBM386208 N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl)-1- propionylpiperidin-3- yl)methanesulfonamide::US10287305, Example 182::US10508083, Example 182::US11292766, Example 182

SMILES CCC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1

InChI Key InChIKey=UOTZWGSJNUWUJV-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 386208   

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386208(N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl...)
Affinity DataEC50:  2.30nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386208(N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl...)
Affinity DataEC50:  2.30nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386208(N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl...)
Affinity DataEC50:  2.30nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386208(N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl...)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386208(N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed