BDBM386760 1-(2-((1R,3S,5R)- 3-((5'-acetyl-2'- chloro-2-fluoro- [1,1'-biphenyl]-3- yl)carbamoyl)-2- azabicyclo[3.1.0] hexan-2-yl)-2- oxoethyl)-5-(2- methylpyrimidin- 5-yl)-1H- pyrazolo[3,4- d]thiazole-3- carboxamide::US10287301, Compound 717::US10822352, Comp No. 717

SMILES CC(=O)c1ccc(Cl)c(c1)-c1cccc(NC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Cn2nc(C(N)=O)c3sc(nc23)-c2cnc(C)nc2)c1F

InChI Key InChIKey=JOJJUWZQUJOUKA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 386760   

TargetComplement factor D(Human)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM386760(1-(2-((1R,3S,5R)- 3-((5'-acetyl-2'- chloro-2-fluor...)
Affinity DataIC50: 1.00E+3nMAssay Description:Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration was incubated with test compound at various conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetComplement factor D(Human)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM386760(1-(2-((1R,3S,5R)- 3-((5'-acetyl-2'- chloro-2-fluor...)
Affinity DataIC50: 1.00E+3nMAssay Description:Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration was incubated with test compound at various conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
US Patent