BDBM386781 (2S,4R)-1-(2-(3- acetyl-5-(2- methylpyrimidin- 5-yl)-1H-indazol- 1-yl)acetyl)-N- (2'-chloro-5'-(N- cyclopropylsulfamoyl)- 2-fluoro- [1,1'-biphenyl]-3- yl)-4- fluoropyrrolidine- 2-carboxamide::US10287301, Compound 745::US10822352, Comp No. 745::US11407738, Cmpd No. 521

SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2cc(ccc2Cl)S(=O)(=O)NC2CC2)c2ccc(cc12)-c1cnc(C)nc1

InChI Key InChIKey=KFBRCSODKHASSW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 386781   

TargetComplement factor D(Human)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM386781((2S,4R)-1-(2-(3- acetyl-5-(2- methylpyrimidin- 5-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration was incubated with test compound at various conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetComplement factor D(Human)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM386781((2S,4R)-1-(2-(3- acetyl-5-(2- methylpyrimidin- 5-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent

TargetComplement factor D(Human)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM386781((2S,4R)-1-(2-(3- acetyl-5-(2- methylpyrimidin- 5-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration was incubated with test compound at various conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
US Patent