BDBM387030 N-[5-[[(3R)-1-(6-fluoropyridazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]-2-methoxy-2[3-(trifluoromethoxy)phenyl]acetamide::US9938265, Example 17::US9938265, Example 18

SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(OC(F)(F)F)c1

InChI Key InChIKey=IDRDCRPUNSAUQG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387030   

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Astrazeneca

US Patent
LigandPNGBDBM387030(US9938265, Example 18 | N-[5-[[(3R)-1-(6-fluoropyr...)
Affinity DataIC50: 24.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Astrazeneca

US Patent
LigandPNGBDBM387030(US9938265, Example 18 | N-[5-[[(3R)-1-(6-fluoropyr...)
Affinity DataIC50: 65.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent