BDBM387046 (2R)-2-methoxy-2-(4-methoxyphenyl)-N-[5-[[(3R)-1-(5-methylpyridazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide and (2S)-2-methoxy-2-(4-methoxyphenyl)-N-[5-[[(3R)-1-(5-methylpyridazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide::US9938265, Example 33(a)::US9938265, Example 33(b)

SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cc(C)cnn2)s1)c1ccc(OC)cc1

InChI Key InChIKey=MAVOVIAMLBQGEA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387046   

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Astrazeneca

US Patent
LigandPNGBDBM387046(US9938265, Example 33(b) | (2R)-2-methoxy-2-(4-met...)
Affinity DataIC50: 79.9nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Astrazeneca

US Patent
LigandPNGBDBM387046(US9938265, Example 33(b) | (2R)-2-methoxy-2-(4-met...)
Affinity DataIC50: 148nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent