BDBM387187 1-(4-((5-chloro-4-((2-(methyl sulfonyl)octahydrocyclopenta[c]pyrrol-5-yl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-2-methylpropan-2-ol::US9938257, Example 39

SMILES CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(C)(=O)=O)n2)cn1

InChI Key InChIKey=VMAMZHADUWRQFW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 387187   

TargetAurora kinase B(Human)
Calitor Sciences

US Patent
LigandPNGBDBM387187(1-(4-((5-chloro-4-((2-(methyl sulfonyl)octahydrocy...)
Affinity DataIC50: 1nMAssay Description:Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

TargetAurora kinase A(Human)
Calitor Sciences

US Patent
LigandPNGBDBM387187(1-(4-((5-chloro-4-((2-(methyl sulfonyl)octahydrocy...)
Affinity DataIC50: 2nMAssay Description:Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Calitor Sciences

US Patent
LigandPNGBDBM387187(1-(4-((5-chloro-4-((2-(methyl sulfonyl)octahydrocy...)
Affinity DataIC50: 2nMAssay Description:JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent