BDBM387337 7-methoxy-N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}quinolin-4-amine::US10292985, Example 20

SMILES COc1ccc2c(Nc3nc(nn4cccc34)-c3cccc(n3)C(F)(F)F)ccnc2c1

InChI Key InChIKey=NPWSJRBJNIOWDX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387337   

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM387337(US10292985, Example 20 | 7-methoxy-N-{2-[6-(triflu...)
Affinity DataIC50: 4.20nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetTGF-beta receptor type-2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM387337(US10292985, Example 20 | 7-methoxy-N-{2-[6-(triflu...)
Affinity DataIC50: 1.50E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent