BDBM387338 N-{2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}-7-methoxyquinolin-4-amine::US10292985, Example 21

SMILES COc1ccc2c(Nc3nc(nn4cccc34)-c3cccc(n3)C(F)F)ccnc2c1

InChI Key InChIKey=GIRCTEUOEKBNDM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387338   

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM387338(US10292985, Example 21 | N-{2-[6-(difluoromethyl)p...)
Affinity DataIC50: 1.80nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetTGF-beta receptor type-2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM387338(US10292985, Example 21 | N-{2-[6-(difluoromethyl)p...)
Affinity DataIC50: 3.12E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent