BDBM387950 Ethyl 2-(4-(6-(5-cyano-1H-pyrazolo[3,4-b]pyridin-1-yl)-4-(isopropylamino)pyridin-3-yl)-1H-1,2,3-triazol-1-yl)acetate (98) and (R)-tert-butyl 2-((4-(6-(5-cyano-1H-pyrazolo[3,4-b]pyridin-1-yl)-4-(isopropylamino)pyridin-3-yl)-1H-1,2,3-triazol-1-yl) methyl)pyrrolidine-1-carboxylate (99)::US10294229, Example 98::US10294229, Example 99

SMILES CC(C)Nc1cc(ncc1-c1cn(C[C@H]2CCCN2C(=O)OC(C)(C)C)nn1)-n1ncc2cc(cnc12)C#N

InChI Key InChIKey=AWYBFCCJEGJOQC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387950   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM387950(US10294229, Example 98 | US10294229, Example 99 | ...)
Affinity DataIC50: 2nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM387950(US10294229, Example 98 | US10294229, Example 99 | ...)
Affinity DataIC50: 8nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent