BDBM388285 1-(5-(5-(3-hydroxy-3-methylbutyl)-4,5-dihydroisoxazol-3-yl)-4-(isopropylamino)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile (Enantiomers 1 and 2)::US10294229, Example 435::US10294229, Example 437

SMILES CC(C)Nc1cc(ncc1C1=NOC(CCC(C)(C)O)C1)-n1ncc2cc(cnc12)C#N

InChI Key InChIKey=LXVPQTIWYGXBLL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 388285   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM388285(US10294229, Example 435 | US10294229, Example 437 ...)
Affinity DataIC50: 2nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM388285(US10294229, Example 435 | US10294229, Example 437 ...)
Affinity DataIC50: 2nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM388285(US10294229, Example 435 | US10294229, Example 437 ...)
Affinity DataIC50: 2nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent