BDBM388829 2-Fluoro-N-(trans-4-hydroxycyclohexyl)-4-[7-(1-quinolin-6-ylethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide::US10738052, Example 159::US11261191, Example 159::US9944645, 159

SMILES CC(c1cnc2ncc(nn12)-c1ccc(C(=O)N[C@H]2CC[C@H](O)CC2)c(F)c1)c1ccc2ncccc2c1

InChI Key InChIKey=PJXCVELEUHKAJM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 388829   

TargetHepatocyte growth factor receptor(Human)
Incyte

US Patent
LigandPNGBDBM388829(US9944645, 159 | 2-Fluoro-N-(trans-4-hydroxycycloh...)
Affinity DataIC50: 500nMAssay Description:Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Incyte

US Patent
LigandPNGBDBM388829(US9944645, 159 | 2-Fluoro-N-(trans-4-hydroxycycloh...)
Affinity DataIC50: 500nMAssay Description:Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Incyte

US Patent
LigandPNGBDBM388829(US9944645, 159 | 2-Fluoro-N-(trans-4-hydroxycycloh...)
Affinity DataIC50: 500nMAssay Description:Briefly, histidine-tagged c-Met catalytic domain fusion protein was used for the assay. IC50 measurements were based on the degree of phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent