BDBM388856 2-Methyl-5-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]isoindolin-1-one::US10738052, Example 186::US11261191, Example 186::US9944645, 186

SMILES CN1Cc2cc(ccc2C1=O)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1

InChI Key InChIKey=BECWJWYXVSNSIQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 388856   

TargetHepatocyte growth factor receptor(Human)
Incyte Holdings

US Patent
LigandPNGBDBM388856(US9944645, 186 | 2-Methyl-5-[3-(1-quinolin-6-ylcyc...)
Affinity DataIC50: 500nMAssay Description:Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Incyte Holdings

US Patent
LigandPNGBDBM388856(US9944645, 186 | 2-Methyl-5-[3-(1-quinolin-6-ylcyc...)
Affinity DataIC50: 500nMAssay Description:Briefly, histidine-tagged c-Met catalytic domain fusion protein was used for the assay. IC50 measurements were based on the degree of phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Incyte Holdings

US Patent
LigandPNGBDBM388856(US9944645, 186 | 2-Methyl-5-[3-(1-quinolin-6-ylcyc...)
Affinity DataIC50: 500nMAssay Description:Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent