BDBM388979 4-(8-[3-(1-hydroxyethyl)-4- methylphenyl]-5-{[(3R)-1- methylpiperidin-3- yl]methoxy}imidazo[1,2- c]pyrimidin-7-yl)benzonitrile::US10800779, Example 93::US11401272, Example 93::US9944647, Example 93

SMILES CC(O)c1cc(ccc1C)-c1c(nc(OC[C@@H]2CCCN(C)C2)n2ccnc12)-c1ccc(cc1)C#N

InChI Key InChIKey=ASRHBXGGKXOZBO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 388979   

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM388979(US9944647, Example 93 | 4-(8-[3-(1-hydroxyethyl)-4...)
Affinity DataIC50: 50nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM388979(US9944647, Example 93 | 4-(8-[3-(1-hydroxyethyl)-4...)
Affinity DataIC50: 50nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM388979(US9944647, Example 93 | 4-(8-[3-(1-hydroxyethyl)-4...)
Affinity DataIC50: 50nMAssay Description:LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent