BDBM390098 US10323037, Example 110::US9951077, 110

SMILES Nc1n[nH]c(=O)c2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C

InChI Key InChIKey=QUYXPVXTKPTPCA-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 390098   

TargetTyrosine-protein kinase BTK(Human)
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM390098(US9951077, 110 | US10323037, Example 110)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using TK1 as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM390098(US9951077, 110 | US10323037, Example 110)
Affinity DataIC50: 505nMAssay Description:The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM390098(US9951077, 110 | US10323037, Example 110)
Affinity DataIC50: 505nMAssay Description:The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM390098(US9951077, 110 | US10323037, Example 110)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells at holding potential of -80 mV by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM390098(US9951077, 110 | US10323037, Example 110)
Affinity DataIC50: 3.73E+4nMAssay Description:Inhibition of human liver microsome CYP3A4 using midazolam as substrate preincubated for 10 mins followed by substrate and NADPH addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM390098(US9951077, 110 | US10323037, Example 110)
Affinity DataIC50: 3.96E+4nMAssay Description:Inhibition of human liver microsome CYP2C9 using diclofenac as substrate preincubated for 10 mins followed by substrate and NADPH addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM390098(US9951077, 110 | US10323037, Example 110)
Affinity DataIC50: 4.39E+4nMAssay Description:Inhibition of human liver microsome CYP2C19 using S-mephenytoin as substrate preincubated for 10 mins followed by substrate and NADPH addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM390098(US9951077, 110 | US10323037, Example 110)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human liver microsome CYP2D6 using dextromethorphan as substrate preincubated for 10 mins followed by substrate and NADPH addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Hubei Bio-Pharmaceutical Industrial Technological Institute

Curated by ChEMBL
LigandPNGBDBM390098(US9951077, 110 | US10323037, Example 110)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human liver microsome CYP1A2 using phenacetin as substrate preincubated for 10 mins followed by substrate and NADPH addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed