BDBM391099 (2S,5S)-tert-butyl 5- (cyanomethyl)-5-(4-oxo-3- ((4-((S or R)-1,1,1-trifluoro- 2-hydroxypropan-2- yl)phenyl)amino)-4,5- dihydro-1H-pyrazolo[4,3- c]pyridin-1-yl)tetrahydro- 2H-pyran-2-carboxylate (from I-14-1A and I-32A)::US9957264, Example 5-170::US9957264, Example 5-171

SMILES CC(C)(C)OC(=O)[C@@H]1CC[C@](CC#N)(CO1)n1nc(Nc2ccc(cc2)C(C)(O)C(F)(F)F)c2c1cc[nH]c2=O

InChI Key InChIKey=WPFVOGVFFHKWNS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 391099   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391099((2S,5S)-tert-butyl 5- (cyanomethyl)-5-(4-oxo-3- ((...)
Affinity DataIC50: 0.0700nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391099((2S,5S)-tert-butyl 5- (cyanomethyl)-5-(4-oxo-3- ((...)
Affinity DataIC50: 0.140nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391099((2S,5S)-tert-butyl 5- (cyanomethyl)-5-(4-oxo-3- ((...)
Affinity DataIC50: 0.180nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391099((2S,5S)-tert-butyl 5- (cyanomethyl)-5-(4-oxo-3- ((...)
Affinity DataIC50: 0.480nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent