BDBM391314 Trans 2-(1-(3-((4- chlorophenyl)amino)-4-oxo- 4,5-dihydro-1H-pyrazolo[4,3- c]pyridin-1-yl)-4-(3- methoxyazetidin-1- yl)cyclohexyl)acetonitrile::US9957264, Example 18-8

SMILES COC1CN(C1)[C@H]1CC[C@@](CC#N)(CC1)n1nc(Nc2ccc(Cl)cc2)c2c1cc[nH]c2=O

InChI Key InChIKey=MECRHGTYHNILSM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391314   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391314(US9957264, Example 18-8 | Trans 2-(1-(3-((4- chlor...)
Affinity DataIC50: 0.0300nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391314(US9957264, Example 18-8 | Trans 2-(1-(3-((4- chlor...)
Affinity DataIC50: 2.53nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent