BDBM391489 (3S,4S)-3-{3-[(2-methyl-1,3-benzothiazol-6-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydro-2H-pyran-4-carbonitrile::US9957265, 2-1

SMILES Cc1nc2ccc(Nc3nn(C4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)cc2s1

InChI Key InChIKey=VXJWYZRDVLGCKC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391489   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391489(US9957265, 2-1 | (3S,4S)-3-{3-[(2-methyl-1,3-benzo...)
Affinity DataIC50: 30nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391489(US9957265, 2-1 | (3S,4S)-3-{3-[(2-methyl-1,3-benzo...)
Affinity DataIC50: 890nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent