BDBM391885 N-((tetrahydro-2H-pyran-4- yl)methyl)-3',4'-dihydro-2'H- spiro[cyclopropane-1,1'- naphthalen]-2-amine::US10301253, Example 35

SMILES C(NC1CC11CCCc2ccccc12)C1CCOCC1

InChI Key InChIKey=WHVQKVOZRCSJCU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391885   

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391885(US10301253, Example 35 | N-((tetrahydro-2H-pyran-4...)
Affinity DataIC50: 37nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391885(US10301253, Example 35 | N-((tetrahydro-2H-pyran-4...)
Affinity DataIC50: 48.5nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent