BDBM391897 3-[(spiro[cyclopropane-2,1'- indane]-1- ylamino)methyl]pyridin-2- amine::US10301253, Example 48

SMILES Nc1ncccc1CNC1CC11CCc2ccccc12

InChI Key InChIKey=KAECBBTWWPYOKJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391897   

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391897(US10301253, Example 48 | 3-[(spiro[cyclopropane-2,...)
Affinity DataIC50: 43.6nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391897(US10301253, Example 48 | 3-[(spiro[cyclopropane-2,...)
Affinity DataIC50: 47.2nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent