BDBM391913 5'-chloro-N-(piperidin-4- ylmethyl)-2',3'- dihydrospiro[cyclopropane- 1,1'-inden]-2-amine::US10301253, Example 64

SMILES Clc1ccc2c(CCC22CC2NCC2CCNCC2)c1

InChI Key InChIKey=MIUQUYBICAZYNK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391913   

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391913(US10301253, Example 64 | 5'-chloro-N-(piperidin-4-...)
Affinity DataIC50: 40.7nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391913(US10301253, Example 64 | 5'-chloro-N-(piperidin-4-...)
Affinity DataIC50: 47.5nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent