BDBM391918 N-(2-(azetidin-3-yl)ethyl)-6'- chloro-2',3'- dihydrospiro[cyclopropane- 1,1'-inden]-2-amine::US10301253, Example 69

SMILES Clc1ccc2CCC3(CC3NCCC3CNC3)c2c1

InChI Key InChIKey=HOZRKHXGEVVWCM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391918   

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391918(US10301253, Example 69 | N-(2-(azetidin-3-yl)ethyl...)
Affinity DataIC50: 38.2nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391918(US10301253, Example 69 | N-(2-(azetidin-3-yl)ethyl...)
Affinity DataIC50: 46.8nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent