BDBM391919 N-(2',3'- dihydrospiro[cyclopropane- 1,1'-inden]-2-yl)-2- azaspiro[3.3]heptan-6-amine::US10301253, Example 70

SMILES C1C(NC2CC3(CNC3)C2)C11CCc2ccccc12

InChI Key InChIKey=KLCWKCRUXOLCAD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391919   

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391919(US10301253, Example 70 | N-(2',3'- dihydrospiro[cy...)
Affinity DataIC50: 30.6nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391919(US10301253, Example 70 | N-(2',3'- dihydrospiro[cy...)
Affinity DataIC50: 32.2nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent