BDBM391938 US10301253, Example 90::US10301253, Example 91

SMILES Clc1cc2CCC3(CC3NCC3CCNCC3)c2cc1Cl

InChI Key InChIKey=YDAIWTSWSYKIAD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 391938   

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391938(US10301253, Example 91 | US10301253, Example 90)
Affinity DataIC50: 29.4nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391938(US10301253, Example 91 | US10301253, Example 90)
Affinity DataIC50: 76.8nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391938(US10301253, Example 91 | US10301253, Example 90)
Affinity DataIC50: 184nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391938(US10301253, Example 91 | US10301253, Example 90)
Affinity DataIC50: 181nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent