BDBM392316 5-amino-3-(4-(aminomethyl)-4-methylpiperidin-1-yl)-6-((2,3-dichlorophenyl)thio)pyrazine-2-carboxamide::US10301278, Example 33

SMILES CC1(CN)CCN(CC1)c1nc(N)c(Sc2cccc(Cl)c2Cl)nc1C#N

InChI Key InChIKey=QHMQLLNKHGNHQU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392316   

LigandPNGBDBM392316(5-amino-3-(4-(aminomethyl)-4-methylpiperidin-1-yl)...)
Affinity DataIC50: 19nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent