BDBM392318 6-(4-amino-4-methylpiperidin-1-yl)-3-((3-chloropyridin-4-yl)thio)pyrazin-2-amine::US10301278, Example 36

SMILES CC1(N)CCN(CC1)c1cnc(Sc2ccncc2Cl)c(N)n1

InChI Key InChIKey=BVRZFBXFDJRGAC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392318   

LigandPNGBDBM392318(6-(4-amino-4-methylpiperidin-1-yl)-3-((3-chloropyr...)
Affinity DataIC50: 76nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent