BDBM392345 US10301278, Example 27a

SMILES C[C@]1(CN)CCN(C[C@H]1O)c1cnc(Sc2cccc(Cl)c2Cl)c(N)n1

InChI Key InChIKey=JFABKFBJKXNMAH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392345   

LigandPNGBDBM392345(US10301278, Example 27a)
Affinity DataIC50: 76nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent