BDBM392585 6-((4-(((6-amino-2,4-dimethylpyridin- 3-yl)methyl)carbamoyl)-3-cyano-1H- pyrazol-1-yl)methyl)-3- chloroquinoline-8-carboxamide::US10301284, Example 72::US10781200, Example 72

SMILES Cc1cc(N)nc(C)c1CNC(=O)c1cn(Cc2cc(C(N)=O)c3ncc(Cl)cc3c2)nc1C#N

InChI Key InChIKey=LXGUFOWDTCMHRM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 392585   

TargetPlasma kallikrein(Human)
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM392585(6-((4-(((6-amino-2,4-dimethylpyridin- 3-yl)methyl)...)
Affinity DataIC50: 100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM392585(6-((4-(((6-amino-2,4-dimethylpyridin- 3-yl)methyl)...)
Affinity DataIC50: 100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
US Patent