BDBM393333 4-Ethoxy-3,3'-difluoro-4'-(((1S,3S)-3-isothiocyanatocyclobutoxy)methyl)-1,1'-biphenyl::US9963444, Example 36

SMILES CCOc1ccc(cc1F)-c1ccc(CO[C@H]2C[C@H](C2)N=C=S)c(F)c1

InChI Key InChIKey=SZKZHHKMMVQLJL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 393333   

TargetN-acylethanolamine-hydrolyzing acid amidase(Human)
Northeastern University

US Patent
LigandPNGBDBM393333(US9963444, Example 36 | 4-Ethoxy-3,3'-difluoro-4'-...)
Affinity DataIC50: 55nMAssay Description:In order to have an assay method more conducive to high-throughput screening than those published for measuring the NAE hydrolyzing activity of NAAA,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
US Patent

TargetN-acylethanolamine-hydrolyzing acid amidase(Human)
Northeastern University

US Patent
LigandPNGBDBM393333(US9963444, Example 36 | 4-Ethoxy-3,3'-difluoro-4'-...)
Affinity DataIC50: 69nMAssay Description:Inhibition of human NAAA using N-(4-methyl coumarin)-palmitamide as fluorogenic substrate preincubated for 90 mins followed by substrate addition by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed