BDBM393430 N-[5-[(2S,5R,6S,7S)-5-amino-6- methoxy-7-methyl-oxepan-2-yl]- 1-methyl-pyrazol-4-yl]-2-(2,6- difluorophenyl)thiazole-4- carboxamide::US9963446, Example 117

SMILES CO[C@H]1[C@H](N)CC[C@H](O[C@H]1C)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C

InChI Key InChIKey=ZNMZBZGLWLFBPB-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 393430   

TargetSerine/threonine-protein kinase pim-1(Human)
Genentech

US Patent
LigandPNGBDBM393430(US9963446, Example 117 | N-[5-[(2S,5R,6S,7S)-5-ami...)
Affinity DataKi:  0.0320nMAssay Description:Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
US Patent