BDBM393439 N-(5-((2R,5S,6R)-5-amino-6- fluorooxepan-2-yl)-1H-pyrazol- 4-yl)-2-(3-methylpyridin-2- yl)thiazole-4-carboxamide::US9963446, Example 127

SMILES N[C@H]1CC[C@@H](OC[C@@H]1F)c1[nH]ncc1NC(=O)c1csc(n1)-c1ccccn1

InChI Key InChIKey=GLEGGRWCRMVSBL-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 393439   

TargetSerine/threonine-protein kinase pim-1(Human)
Genentech

US Patent
LigandPNGBDBM393439(US9963446, Example 127 | N-(5-((2R,5S,6R)-5-amino-...)
Affinity DataKi:  1.10nMAssay Description:Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
US Patent