BDBM393441 N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1H-pyrazol- 4-yl)-2-(2,6- difluorophenyl)thiazole-4- carboxamide::US9963446, Example 129

SMILES N[C@@H]1CC[C@H](OC[C@H]1F)c1[nH]ncc1NC(=O)c1csc(n1)-c1c(F)cccc1F

InChI Key InChIKey=AEZKBPNKHPAXLK-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 393441   

TargetSerine/threonine-protein kinase pim-1(Human)
Genentech

US Patent
LigandPNGBDBM393441(US9963446, Example 129 | N-(5-((2S,5R,6S)-5-amino-...)
Affinity DataKi:  0.958nMAssay Description:Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
US Patent